Thermo Fisher Scientific ALX4 Monoclonal Antibody (OTI2E1), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The ALX4 gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue.
Mutations in ALX4 cause parietal foramina 2 (PFM2), an autosomal dominant disease with deficient ossification of parietal bones.
Other mutations lead to frontonasal dysplasia with alopecia and hypogonadism, implicating ALX4 in craniofacial development and hair follicle formation.
Chromosome 11 deletions involving ALX4 (del(11)(p11p12)) result in Potocki-Shaffer syndrome (PSS), characterized by craniofacial anomalies, mental retardation, and skeletal defects.
In mouse, ALX4 exhibits dual translation initiation sites located 16 codons apart.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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