Thermo Fisher Scientific IL-1 beta Recombinant Superclonal Antibody (17HCLC)

Thermo Fisher Scientific IL-1 beta Recombinant Superclonal Antibody (17HCLC)

Applications and Tested Dilutions

• Western Blot (WB): 1–3 µg/mL
• Immunocytochemistry (ICC/IF): 1 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with non-human primate, rat, and mouse based on sequence homology.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They consist of multiple recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.

These antibodies recognize multiple epitope sites on the target, providing higher detection sensitivity for low-abundance targets. Each lot is produced with a known mixture of light and heavy chains, eliminating biological variability typically found in polyclonal antibody production.

Note: Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”. The product and performance remain unchanged.

Target Information

Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol. Activation of inflammasomes triggers cleavage of pro-IL-1β into the active 17 kDa form via caspase-1 processing.

IL-1β lacks a classical signal sequence and is secreted through an alternate mechanism. It signals through IL-1RI and IL-1RII receptors, shared with IL-1α, and its activity is regulated by IL-1 Receptor Antagonist (IL-1RA).

IL-1β plays a key role in innate host defense, inducing other cytokines and acute-phase responses. Elevated levels are associated with chronic inflammatory conditions, making IL-1β neutralizing antibodies of potential therapeutic interest.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.