Thermo Fisher Scientific CD137L/4-1BBL/TNFSF9 Monoclonal Antibody (CD137L, 1547)
인간 CD137L 단백질을 인식하는 Mouse monoclonal 항체로, IHC, ICC/IF, Flow Cytometry에 적합합니다. Protein A/G 정제, PBS 기반 buffer에 보관되며 4°C에서 안정적으로 유지됩니다. 면역조직화학 및 T세포 활성 연구에 활용됩니다.
- 카탈로그번호
- 8744-MSM1-P0
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1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD137L/4-1BBL/TNFSF9 Monoclonal Antibody (CD137L, 1547)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–4 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD137L, 1547 |
| Immunogen | Recombinant full-length human CD137L protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
CD137 ligand (CD137L) is a type II membrane protein and a member of the TNF superfamily. It acts as a co-stimulatory molecule expressed on antigen-presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation.
Its receptor, CD137 (4-1BB), is expressed on various cell types including inflamed endothelial cells and activated T cells. Interaction between CD137 and CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity.
CD137L expression is observed in most B-cell lymphomas (mantle cell, follicular, diffuse large B-cell) but absent in Hodgkin and T-cell lymphomas. It is also found in carcinoma cell lines, suggesting a role in T cell–tumor cell interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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