Thermo Fisher Scientific CD137L/4-1BBL/TNFSF9 Monoclonal Antibody (CD137L, 1547)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• For immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

CD137 ligand (CD137L) is a type II membrane protein and a member of the TNF superfamily.
It functions as a co-stimulatory molecule expressed on antigen-presenting cells such as dendritic cells, monocytes/macrophages, and B cells, and is upregulated upon activation.

Its receptor, CD137/4-1BB, is expressed on various cells including inflamed endothelial cells and activated T cells.
Engagement of CD137 with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity.

CD137L is expressed on most B-cell lymphomas (mantle cell, follicular, diffuse large B-cell lymphoma), but not on Hodgkin or T-cell lymphomas.
It is also found in carcinoma cell lines and is thought to play a role in T cell–tumor cell interactions.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.