Thermo Fisher Scientific CD137L/4-1BBL/TNFSF9 Monoclonal Antibody (CD137L, 1547)
CD137L/4-1BBL/TNFSF9 단일클론 항체로 인간 CD137L 단백질을 인식합니다. 면역조직화학, 면역세포화학, 유세포분석에 사용 가능하며, Protein A/G로 정제된 액상 항체입니다. -20°C 이하 보관하며 연구용으로만 사용됩니다.
- 카탈로그번호
- 8744-MSM1-P1ABX
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–4 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD137L, 1547 |
| Immunogen | Recombinant full-length human CD137L protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
CD137 ligand (CD137L) is a type II membrane protein and a member of the TNF superfamily.
It functions as a co-stimulatory molecule expressed on antigen-presenting cells such as dendritic cells, monocytes/macrophages, and B cells, and is upregulated upon activation.
Its receptor, CD137/4-1BB, is expressed on various cells including inflamed endothelial cells and activated T cells.
Engagement of CD137 with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity.
CD137L is expressed on most B-cell lymphomas (mantle cell, follicular, diffuse large B-cell lymphoma), but not on Hodgkin or T-cell lymphomas.
It is also found in carcinoma cell lines and is thought to play a role in T cell–tumor cell interactions.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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