Thermo Fisher Scientific CIC Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,500

View 5 publications 5 publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:50

View 1 publication 1 publication

Immunoprecipitation (IP)

2-5 µg/mg lysate

-

ChIP assay (ChIP)

-

View 2 publications 2 publications

Product Specifications

Species Reactivity

Dog, Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide made to a region within residues 1500-1608 of the human Capicua protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CIC,uniProtId:Q96RK0-1,ncbiNodeId:9606,antigenRange:1500-1608,antigenLength:1608,antigenImageFileName:PA1-46018_CIC_Q96RK0-1_Rabbit.svg,antigenImageFileNamePDP:PA1-46018_CIC_Q96RK0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2291736

Product Specific Information

By Western blot, PA1-46018 is specific for the ~250 kDa CIC protein.

CIC (164 kDa) interacts with Ataxin 1 (87 kDa).

This may explain the band at 250 kDa (complex).Suggested positive control: Hela whole cell extract.

Target Information

This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.