Thermo Fisher Scientific Phospho-EP2 Prostanoid Receptor (Thr344, Ser345) Polyclonal Antibody
EP2 프로스타노이드 수용체의 Thr344/Ser345 인산화 부위를 인식하는 토끼 폴리클로날 항체. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. 인체 시료 반응, 액상 형태, 장기 보관 시 -20°C 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human EP2 around the phosphorylation site of Thr344/Ser345 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 (PGE2) is one of the five physiologically significant prostanoids. Its wide range of physiological and pharmacological effects in various tissues is mediated through binding to Prostaglandin E2 receptors (EP1, EP2, EP3, and EP4). These receptors influence immune, endocrine, cardiovascular, renal, and reproductive systems, as well as smooth muscle activity.
PGE2 is abundant in the brain, where it plays a key role in neural functions, especially in newborns, and acts as a mediator of inflammation. EP2 receptors are G-protein coupled receptors (GPCRs) that stimulate adenylyl cyclase via coupling to Gs proteins and do not undergo PGE2-induced internalization. EP2 receptors are involved in smooth muscle contraction and relaxation and are mainly localized in lung and placental tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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