Thermo Fisher Scientific Phospho-EP2 Prostanoid Receptor (Ser347, Thr348) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000
• Publications: -

Product Specifications

Target Information

Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 (PGE2) is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues is mediated through binding to the Prostaglandin E2 receptors (EP1, EP2, EP3, and EP4).
These effects include modulation of immune, endocrine, cardiovascular, renal, and reproductive systems, as well as smooth muscle function. PGE2 is abundant in the brain, where it plays an important role in neural functions and inflammation, particularly in newborns.

EP2 receptors are G-protein coupled receptors consisting of 358 amino acids with a short third intracellular loop. They stimulate adenylyl cyclase via coupling to Gs and do not undergo PGE2-induced internalization. EP2 receptors are involved in smooth muscle contraction and relaxation and are mainly localized in lung, placental, and smooth muscle tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.