Thermo Fisher Scientific CATSPER3 Polyclonal Antibody
CATSPER3 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot에 적합합니다. 인간 및 생쥐 시료 반응성이 있으며, 정자 운동성과 수정을 연구하는 데 유용합니다. 항원 친화 크로마토그래피로 정제되었습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human cation channel, sperm associated 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635827 |
Product Specific Information
This antibody detects endogenous levels of total CATSPER3 protein.
Target Information
CatSpers (cation channel, sperm associated proteins) are ion transport proteins located on the surface of sperm cells, particularly in the principal piece of the sperm tail. These proteins are essential for sperm motility, fertilization, and cAMP-mediated calcium influx.
There are four CatSper proteins in mammalian sperm — CatSper1, CatSper2, CatSper3, and CatSper4 — each containing a single six-transmembrane-spanning segment and forming a voltage-dependent Ca²⁺ channel.
CatSper proteins assemble into a heterotetrameric complex that functions as an alkalinization-activated, Ca²⁺-selective channel. Mutations in any CatSper gene can lead to male infertility.
CatSper3, in particular, plays a critical role in the hyperactivated motility of sperm cells, a process required for successful fertilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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