Thermo Fisher Scientific CATSPER3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total CATSPER3 protein.

Target Information

CatSpers (cation channel, sperm associated proteins) are ion transport proteins located on the surface of sperm cells, particularly in the principal piece of the sperm tail. These proteins are essential for sperm motility, fertilization, and cAMP-mediated calcium influx.
There are four CatSper proteins in mammalian sperm — CatSper1, CatSper2, CatSper3, and CatSper4 — each containing a single six-transmembrane-spanning segment and forming a voltage-dependent Ca²⁺ channel.
CatSper proteins assemble into a heterotetrameric complex that functions as an alkalinization-activated, Ca²⁺-selective channel. Mutations in any CatSper gene can lead to male infertility.
CatSper3, in particular, plays a critical role in the hyperactivated motility of sperm cells, a process required for successful fertilization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.