Thermo Fisher Scientific KRAS Monoclonal Antibody (OTI5H6), TrueMAB
KRAS 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot에 최적화됨. 인간 종에 반응하며, 동결건조 형태로 제공. 세포 증식 및 암 관련 연구에 적합. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5H6 |
| Immunogen | Full length human recombinant protein of human KRAS produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
K-RAS (GTPase KRas) is a member of the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
It plays a key role in cell proliferation regulation and can promote oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner.
Mutations in KRAS are associated with acute myelogenous leukemia, juvenile myelomonocytic leukemia, Noonan Syndrome, gastric cancer, and cardiofaciocutaneous syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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