Thermo Fisher Scientific Aggrecan Monoclonal Antibody (969D4D11)
Thermo Fisher Scientific의 Aggrecan Monoclonal Antibody (969D4D11)은 인간 연골 조직에서 정제된 aggrecan을 면역원으로 한 마우스 IgG1 단일클론 항체입니다. Western blot, IHC, ELISA 등 다양한 응용에 사용 가능하며, 단백질 A로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 3 publications |
| Immunohistochemistry (IHC) | Assay-dependent | View 7 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 5 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 4 publications |
| Immunocytochemistry (ICC/IF) | - | View 3 publications |
| Flow Cytometry (Flow) | - | View 1 publication |
| ELISA | Assay-dependent | View 8 publications |
| Immunoprecipitation (IP) | - | View 1 publication |
| Neutralization (Neu) | - | View 1 publication |
| Functional Assay | - | View 1 publication |
| In vitro Assay (IV) | - | View 1 publication |
| Miscellaneous PubMed | - | View 5 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Bovine, Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 969D4D11 |
| Immunogen | Human natural aggrecan (proteoglycan), purified from human articular cartilage |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.5 mg/mL sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536346 |
Product Specific Information
This product is recommended as a detection antibody in Sandwich ELISA applications.
This clone can also be referred to as clone number 969D 4D11 2A9.
Target Information
Aggrecan, also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is encoded by the ACAN gene.
It is a major structural component of the extracellular matrix in cartilage, providing resistance to compression. The human protein consists of 2316 amino acids (~250 kDa) and exists in multiple isoforms due to alternative splicing.
Aggrecan has a bottlebrush structure with chondroitin sulfate and keratan sulfate chains attached to a protein core. It includes three interglobular domains (G1, G2, G3) involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis.
Fragments of aggrecan are released into synovial fluid during osteoarthritis due to cleavage by aggrecanase and MMPs. Antibodies BC-3 and BC-4 can detect neo epitopes of aggrecanase (ARGSVXXX) and MMP (XXXVDIPEN), respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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