Thermo Fisher Scientific CD183 (CXCR3) Monoclonal Antibody (CXCR3-173), PE, eBioscience
마우스 CD183(CXCR3)을 인식하는 PE-conjugated 단클론 항체로, Flow Cytometry에 최적화되어 있습니다. CXCR3 리간드 결합 및 T세포 반응 연구에 유용하며, 0.25 µg/test 농도로 사용 가능합니다. 4°C에서 암소 보관하며, 동결 금지.
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Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 0.25 µg/test
- Publications: View 23 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CXCR3-173 |
| Conjugate | PE |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1210735 |
Additional Available Formats
- APC
- Biotin
- Brilliant Violet 421
- Brilliant Violet 480
- FITC
- Functional Grade
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Blue 690
- PE-Cyanine7
- PE-eFluor 610
- PerCP-Cyanine5.5
- Super Bright 436
- Super Bright 600
- Request custom conjugation
Product Specific Information
The monoclonal antibody CXCR3-173 recognizes mouse CD183 (CXCR3), a seven-transmembrane G-protein-coupled chemokine receptor that binds CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (ITAC). CD183 plays a critical role in CD4 T cell responses to grafts, and CXCR3 knockout mice show compromised allograft rejection.
Expression is found on NK cells, subsets of T lymphocytes and Tregs, with preferential expression on Th1-polarized cells.
The CXCR3-173 antibody affects chemotaxis in response to ligand; ligand presence eliminates staining. In vivo addition delays cardiac and pancreatic islet allograft rejection.
- Reported Applications: Flow cytometric analysis
- Tested Applications: Flow cytometry of mouse splenocytes
- Recommended Usage: ≤ 0.25 µg/test in 100 µL final volume (cell number 10⁵–10⁸ cells/test)
- Excitation: 488–561 nm
- Emission: 578 nm
- Laser Compatibility: Blue, Green, Yellow-Green lasers
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
This gene encodes a G protein-coupled receptor selective for chemokines IP10, Mig, and I-TAC. These chemokines belong to the CXC subfamily, characterized by a single amino acid separating the first two conserved cysteines. Binding induces leukocyte activation, cytoskeletal rearrangement, and chemotactic migration.
Inhibition by Bordetella pertussis toxin suggests coupling to Gi-class G proteins. Signal transduction likely involves pathways common to other chemokine receptors. Chemokine-induced desensitization occurs via phosphorylation-dependent receptor internalization, with subsequent recycling restoring responsiveness.
CXCR3 is prominently expressed in effector/memory T cells and inflamed tissues, where its ligands are locally produced. It is a key target for small-molecule antagonist development for inflammatory disease therapy. Multiple transcript variants exist, encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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