Thermo Fisher Scientific CD183 (CXCR3) Monoclonal Antibody (CEW33D), PE, eBioscience
인간 CD183(CXCR3)을 인식하는 CEW33D 단클론 항체로, PE 형광체가 결합된 유세포분석용 항체입니다. 활성화된 T세포, NK세포 등 Th1 면역반응 관련 세포 분석에 적합합니다. 5 µL/test로 사용하며, 4°C 암소 보관합니다.
- 카탈로그번호
- 12-1839-4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD183 (CXCR3) Monoclonal Antibody (CEW33D), PE, eBioscience
Applications
- Flow Cytometry (Flow): 5 µL (0.25 µg)/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CEW33D |
| Conjugate | PE |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572588 |
Available Formats
- APC
- Biotin
- Brilliant UV 615
- eFluor 660
- NovaFluor Blue 660-120S
- NovaFluor Red 685
- NovaFluor Red 710
- NovaFluor Red 725
- NovaFluor Yellow 690
- PE-Cyanine7
- PE-eFluor 610
- Request custom conjugation
Product Specific Information
The CEW33D monoclonal antibody reacts with human CD183 (CXCR3), a G protein-coupled chemokine receptor that binds CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC). CD183 is associated with type 1 immunity and is expressed in activated T cells, Th1 cells, CD8 effector cells, NK cells, and NKT cells. It mediates infiltration of inflamed tissues in normal immune responses and inflammatory diseases. CD183 is also found on some B cells and plasmacytoid dendritic cells.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and validated for flow cytometry using normal human peripheral blood cells.
Use at 5 µL (0.25 µg) per test. A test is defined as the amount of antibody to stain cells in 100 µL final volume, typically 10⁵–10⁸ cells/test.
Excitation: 488–561 nm
Emission: 578 nm
Laser: Blue, Green, or Yellow-Green Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
This gene encodes a G protein-coupled receptor that selectively binds chemokines IP-10, Mig, and I-TAC. These ligands belong to the CXC chemokine family, which mediate leukocyte trafficking, integrin activation, cytoskeletal rearrangements, and chemotaxis. CD183 signaling involves Gi-class G proteins and may share pathways with other chemokine receptors. The receptor undergoes phosphorylation-dependent internalization and recycling, leading to transient cellular responses. CD183 is expressed in effector/memory T cells and inflamed tissues, implicating it in inflammatory cell recruitment. It is a potential target for small-molecule antagonists in inflammatory disease treatment. Multiple transcript variants exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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