Thermo Fisher Scientific FOXP3 Monoclonal Antibody (3G3), FITC

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

1 µL/1 million cells

View 1 publication 1 publication

Immunoprecipitation (IP)

-

View 10 publications 10 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Fruit fly, Human, Mouse, Rabbit

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

3G3

Immunogen

Full-length, His-tagged murine FOXP3. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FOXP3,uniProtId:Q99JB6-1,ncbiNodeId:10090,antigenRange:1-429,antigenLength:429,antigenImageFileName:MA1-41628_FOXP3_Q99JB6-1_House_mouse.svg,antigenImageFileNamePDP:MA1-41628_FOXP3_Q99JB6-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

FITC FITC FITC

View additional formats

• Unconjugated
• APC
• Request custom conjugation

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

1.85 mg/mL

Purification

Protein G

Storage buffer

50mM sodium borate

Contains

0.05% sodium azide

Storage conditions

4° C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1074471

Product Specific Information

MA1-41628 is derived from full-length His-tagged mouse FOXP3. The precise epitope is not known, but it has been mapped to the N-terminal portion of the protein.

Target Information

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.