Thermo Fisher Scientific Human IL-8 (CXCL8) (72 aa), Animal-Free Recombinant Protein, PeproTech

Applications

ELISA

• Tested Dilution: Not specified
• View 1 publication

Functional Assay

• Assay-dependent
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In vitro Assay

• Tested Dilution: Not specified
• View 4 publications

Product Specifications

Product Specific Information

Recombinant Human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.

Target Information

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines. It binds to IL-8RA and IL-8RB receptors and functions as a chemoattractant and potent angiogenic factor.
IL-8 expression can be induced by various inflammatory stimuli in macrophages and endothelial cells. In endothelial cells, IL-8 is stored in Weibel-Palade bodies.
Originally isolated from osteosarcoma cells, IL-8 contains an ELR-motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors.
Previous names include NAP-1, GCP-1, MONAP, and protein 3-10C. IL-8 and related chemokines form a gene cluster on chromosome 4q.
IL-8 plays roles in tumor angiogenesis and growth, and in the pathogenesis of bronchiolitis, a viral respiratory disease.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.