Thermo Fisher Scientific UFD1L Polyclonal Antibody
Thermo Fisher Scientific의 UFD1L Polyclonal Antibody는 인체 및 생쥐 시료에 반응하며, Western blot, ICC/IF, ELISA에 적합합니다. 고순도 친화 크로마토그래피 정제 항체로, 세포질 및 핵 내 UFD1L 단백질 검출에 유용합니다. 연구용 전용 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein corresponding to amino acids 1–307 of human UFD1L (NP_005650.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.28 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914436 |
Product Specific Information
- Positive test controls: MCF7, A-431, Mouse heart
- Subcellular localization: Cytoplasm, Nucleus, Cytosol
Immunogen sequence:
MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP SALDQLSRLN ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ NLLLEEGGLV QVESVNLQVA TYSKFQPQSP DFLDITNPKA VLENALRNFA CLTTGDVIAI NYNEKIYELR VMETKPDKAV SIIECDMNVD FDAPLGYKEP ERQVQHEEST EGEADHSGYA GELGFRAFSG SGNRLDGKKK GVEPSPSPIK PGDIKRGIPN YEFKLGKITF IRNSRPLVKK VEEDEAGGRF VAFSGEGQSL RKKGRKP
Target Information
Ubiquitin-mediated proteolysis involves transferring ubiquitin (Ub) to lysine residues on target proteins, marking them for degradation by the 26S proteasome. UFD1L plays a role in this pathway by regulating the degradation of Ub-fusion proteins. Originally identified in yeast and later in humans, UFD1L modulates multiubiquitination processes. Mutations in UFD1L are associated with CATCH22 syndrome, which includes cardiac defects, cleft palate, and hypocalcemia, suggesting its role in developmental processes.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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