Thermo Fisher Scientific MSLN Monoclonal Antibody (OTI1B7), TrueMAB
Human mesothelin 단백질(aa 270–493)을 인식하는 mouse monoclonal antibody로 Western blot에 적합. Lyophilized 형태, PBS buffer(8% trehalose) 구성, carrier-free로 conjugation 실험에 활용 가능. 암 관련 Mesothelin 연구용으로 최적화된 TrueMAB 제품.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B7 |
| Immunogen | Human recombinant protein fragment (aa 270–493 of human MSLN, produced in E. coli) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Mesothelin is a GPI-anchored, cell-surface glycoprotein expressed by mesothelial cells and aberrantly overexpressed in several cancers, including mesotheliomas, ovarian cystadenocarcinomas, and pancreatic adenocarcinomas.
Proteolytic cleavage generates a soluble fragment known as megakaryocyte potentiating factor (MPF), which may influence megakaryocyte proliferation and platelet production.
High-level expression in tumors versus limited distribution in normal tissues suggests involvement in tumorigenesis, cell adhesion, and metastatic progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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