Thermo Fisher Scientific STAR Polyclonal Antibody
Thermo Fisher Scientific의 STAR Polyclonal Antibody는 인간 및 마우스 시료에 반응하며, Western blot과 Immunoprecipitation에 적합합니다. Rabbit IgG 기반의 비결합 항체로, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 콜레스테롤 대사 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunoprecipitation (IP)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human STAR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719828 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is greater than 95% (by SDS-PAGE).
Target Information
Steroidogenic acute regulatory protein (StAR) plays a crucial role in transporting cholesterol from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein that facilitates cholesterol metabolism into pregnenolone. StAR is predominantly expressed in mitochondria of steroid-producing adrenal and gonadal tissues. Abnormalities in StAR gene expression are associated with autosomal Lipoid Congenital Adrenal Hyperplasia (LCAH), resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR remains to be elucidated.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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