Thermo Fisher Scientific NUP107 Polyclonal Antibody
Thermo Fisher Scientific의 NUP107 Polyclonal Antibody는 인간 NUP107 단백질을 특이적으로 인식하는 항체로, Western blot, ICC/IF, IP 등 다양한 응용에 적합합니다. 보존제가 없으며 장기 보관 시 -20°C에서 안정적입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:1,500–1:50,000 |
| Immunoprecipitation (IP) | 1–2 µL/mg of lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminus of Human NUP107 (UniProt ID: P57740-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | 2–8°C for up to 1 month; for long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788732 |
Product Specific Information
- Preservative-free formulation
- Recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination
- Specificity: Human Nup107
Target Information
The nuclear pore complex (NPC) is a protein assembly at the nuclear rim that mediates macromolecular transport between the nucleus and cytoplasm. Mammalian nucleoporin NUP107 is part of a hetero-oligomeric complex with NUP160, NUP133, NUP96, and sec13p.
A fraction of NUP107-160 complex localizes to kinetochores and spindle poles during mitosis, interacting with proteins such as Mad1, Mad2, Bub3, and Cdc20. Immunodepletion of this complex results in defective spindle assembly, indicating multiple functions.
NUP107 has been identified as an HIV dependency factor (HDF), suggesting its potential as a drug target in HIV treatment. Multiple isoforms of NUP107 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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