Thermo Fisher Scientific PD-1 Recombinant Rabbit Monoclonal Antibody (BLR076G)
PD-1 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, 인체 시료에 반응합니다. IHC(P) 실험에 적합하며, 고순도 정제 상태로 제공됩니다. 세포 면역 반응 연구 및 PD-1/PD-L1 경로 분석에 유용합니다. 4°C에서 보관하며 연구용으로만 사용 가능합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:100 - 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR076G |
| Immunogen | Recombinant protein representing the extracellular domain of human PD-1 (residues 24–164) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1000 µg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 7.8–8.6 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). Activated T cells express receptors such as PD-1 (PDCD-1) that mediate inhibitory signals from APCs. PD-1 binds to ligands PDL-1 and PDL-2, and upon binding, inhibits immune activation in the absence of danger signals such as LPS. PD-1 deficient mice exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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