Thermo Fisher Scientific PCNA Recombinant Rabbit Monoclonal Antibody (BLR075G)
Thermo Fisher Scientific의 PCNA Recombinant Rabbit Monoclonal Antibody (BLR075G)는 인간 PCNA 단백질을 표적으로 하는 고특이성 항체입니다. Western blot, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합하며, HEK293 발현 시스템 기반 정제 항체로 높은 재현성과 안정성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 - 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 - 1:500 |
| Flow Cytometry (Flow) | 1 µL per 1 x 10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR075G |
| Immunogen | Peptide representing a region between residue 225 and the C-terminus (residue 261) of human Proliferating Cell Nuclear Antigen (PCNA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 10 µg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 7.8–8.6, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Target Information
PCNA (Proliferating Cell Nuclear Antigen) is a polymerase delta auxiliary protein essential for DNA replication and repair. It interacts with CDK inhibitor p21, endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA serves as a marker for proliferating cells and tumor prognosis, being expressed during early G1 and S phases. Located in the nucleus, PCNA functions as a homotrimer that enhances DNA polymerase delta activity during replication. Upon DNA damage, PCNA undergoes ubiquitination and participates in the RAD6-dependent DNA repair pathway. Two transcript variants encode the same protein, and pseudogenes are found on chromosome 4 and the X chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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