Thermo Fisher Scientific ABCC5 Monoclonal Antibody (OTI5F4), TrueMAB
ABCC5 단백질을 표적하는 단클론 항체로, Western blot에 최적화됨. 인간, 생쥐, 랫트 반응성. 무보존제, 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능. 연구용으로만 사용.
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Thermo Fisher Scientific ABCC5 Monoclonal Antibody (OTI5F4), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F4 |
| Immunogen | Full length human recombinant protein of human ABCC5 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting.
Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
The ABCC5 protein belongs to the ATP-binding cassette (ABC) transporter superfamily, which mediates molecular transport across cellular membranes.
It is part of the MRP subfamily associated with multidrug resistance and facilitates the export of cyclic nucleotides, contributing to their degradation and elimination.
ABCC5 provides resistance to thiopurine anticancer drugs (6-mercaptopurine, thioguanine) and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine.
This protein may play a role in thiopurine resistance in acute lymphoblastic leukemia and antiretroviral nucleoside analog resistance in HIV-infected patients.
Alternative splicing has been observed, though complete sequence and translation initiation sites remain unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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