Thermo Fisher Scientific CD19 Monoclonal Antibody (SJ25-C1), PE-Cyanine7

Applications

Flow Cytometry (Flow)

• Tested Dilution: Assay-Dependent
• Publications: View 2 publications

Miscellaneous PubMed (Misc)

• Publications: View 1 publication

Product Specifications

Additional Available Formats

• Alexa Fluor 488
• Alexa Fluor 700
• APC
• APC-Alexa Fluor 750
• FITC
• Pacific Blue
• PE
• PE-Alexa Fluor 610
• PE-Cyanine5.5
• PE-Texas Red
• PerCP
• Qdot 605
• Qdot 655
• Qdot 800
• TRI-COLOR
• Custom conjugation available upon request

Product Specific Information

The R-phycoerythrin (PE)-Cy7 tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a 488 nm laser without occupying traditional channels associated with FITC and PE. Alternatively, the PE dye tandem can be excited using a 532 nm or 561 nm laser.

Target Information

CD19 is a member of the immunoglobulin superfamily and has two Ig-like domains. It is expressed on 100% of peripheral B cells defined by kappa or lambda light chains and may also be expressed on myeloid leukemia cells, particularly those of monocytic lineage.
CD19 acts as a signal-amplifying coreceptor for the B cell receptor (BCR), lowering the threshold for antigen receptor-dependent stimulation. Mutations in the CD19 gene can cause hypogammaglobulinemia, while overexpression leads to B cell hyperactivity.
CD19 is thus a crucial regulator of normal and malignant B cell proliferation and a key marker in B cell precursor leukemia studies.

Analyte Specific Reagent

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