Thermo Fisher Scientific CD19 Monoclonal Antibody (SJ25-C1), PE-Cyanine7
인간 CD19 단백질을 인식하는 마우스 단클론 항체로, PE-Cyanine7 형광체로 결합되어 다중 색상 유세포 분석에 적합합니다. B세포 표지 연구, 백혈병 세포 분석 등에 활용되며, 488nm 레이저로 효율적 여기 가능합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-Dependent
- Publications: View 2 publications
Miscellaneous PubMed (Misc)
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SJ25-C1 |
| Immunogen | Nalm 1 Human cell line |
| Conjugate | PE-Cyanine7 |
| Excitation / Emission Max | 569 / 780 nm |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS with 4 mg/mL BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10373666 |
Additional Available Formats
- Alexa Fluor 488
- Alexa Fluor 700
- APC
- APC-Alexa Fluor 750
- FITC
- Pacific Blue
- PE
- PE-Alexa Fluor 610
- PE-Cyanine5.5
- PE-Texas Red
- PerCP
- Qdot 605
- Qdot 655
- Qdot 800
- TRI-COLOR
- Custom conjugation available upon request
Product Specific Information
The R-phycoerythrin (PE)-Cy7 tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a 488 nm laser without occupying traditional channels associated with FITC and PE. Alternatively, the PE dye tandem can be excited using a 532 nm or 561 nm laser.
Target Information
CD19 is a member of the immunoglobulin superfamily and has two Ig-like domains. It is expressed on 100% of peripheral B cells defined by kappa or lambda light chains and may also be expressed on myeloid leukemia cells, particularly those of monocytic lineage.
CD19 acts as a signal-amplifying coreceptor for the B cell receptor (BCR), lowering the threshold for antigen receptor-dependent stimulation. Mutations in the CD19 gene can cause hypogammaglobulinemia, while overexpression leads to B cell hyperactivity.
CD19 is thus a crucial regulator of normal and malignant B cell proliferation and a key marker in B cell precursor leukemia studies.
Analyte Specific Reagent
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