Thermo Fisher Scientific SLC22A17 Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000–1:3,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total SLC22A17.

Target Information

The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver.
Each contains 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2.
Transporters of the SLC22 family function in different ways such as:

• Uniporters that mediate facilitated diffusion in either direction (OCTs)
• Anion exchangers (OAT1, OAT3, URAT1)
• Na(+)/L-carnitine cotransporter (OCTN2)

Slc22 family members participate in absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart.
Mutations in the Slc22 family may cause diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may alter drug absorption or excretion.
Recent studies show high expression of Slc22A17 as a receptor for Lipocalin 2 in hematopoietic stem cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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