Thermo Fisher Scientific SLC22A17 Polyclonal Antibody
SLC22A17 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot에 최적화됨. Human, Mouse, Rat 반응성. 액상 형태, 1 mg/mL 농도, PBS/glycerol buffer에 보존. 연구용으로만 사용 가능.
- 카탈로그번호
- PA5103667
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific SLC22A17 Polyclonal Antibody
Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SLC22A17 (Accession Q8WUG5), corresponding to amino acid residues A483–T533 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853001 |
Product Specific Information
Antibody detects endogenous levels of total SLC22A17.
Target Information
The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver.
Each contains 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2.
Transporters of the SLC22 family function in different ways such as:
- Uniporters that mediate facilitated diffusion in either direction (OCTs)
- Anion exchangers (OAT1, OAT3, URAT1)
- Na(+)/L-carnitine cotransporter (OCTN2)
Slc22 family members participate in absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart.
Mutations in the Slc22 family may cause diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may alter drug absorption or excretion.
Recent studies show high expression of Slc22A17 as a receptor for Lipocalin 2 in hematopoietic stem cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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