Thermo Fisher Scientific BRAP Polyclonal Antibody
BRAP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, 인체 유래 BRAP 펩타이드로 면역생성. 고순도 친화 크로마토그래피 정제, 액상 형태로 -20°C 보관.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
- Publications: References
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BRAP (Accession Q7Z569), corresponding to amino acid residues E556–K592 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2853002 |
Product Specific Information
Antibody detects endogenous levels of total BRAP.
Target Information
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes, probably by inactivation of the KSR1 scaffold protein. Acts as a Ras-responsive E3 ubiquitin ligase that, upon activation of Ras, undergoes auto-polyubiquitination, leading to release of inhibition of Raf/MEK complex formation. May also function as a cytoplasmic retention protein involved in regulating nuclear transport.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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