Thermo Fisher Scientific PPP3R1 Polyclonal Antibody
PPP3R1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, Western blot에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 액상 형태로 제공됩니다. Affinity chromatography로 정제되었으며, -20°C에서 보관합니다.
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Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PPP3R1 (Accession P63098), corresponding to amino acid residues K117–V167 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2853004 |
Product Specific Information
Antibody detects endogenous levels of total PPP3R1.
Target Information
Calcineurin is a Ser/Thr, calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. It consists of two subunits:
- Calcineurin A (CnA): 60 kDa catalytic subunit, homologous to protein phosphatases 1 and 2A
- Calcineurin B (CnB): 19 kDa regulatory subunit containing four EF-hand calcium-binding sites
Calcineurin-mediated dephosphorylation of NF-AT is essential for its activation, nuclear translocation, and gene expression in T-cells. Immunosuppressive drugs such as cyclosporin A and FK506 inhibit NF-AT activation by forming complexes with immunophilins that block substrate access to the catalytic domain of CnA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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