Thermo Fisher Scientific CABIN1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total CABIN1.

Target Information

Calcineurin binding protein (Cabin-1) and the corresponding rat homolog, Cain, are widely expressed nuclear phosphoproteins that regulate the serine/threonine phosphatase activity of calcineurin and influence T cell signaling and apoptosis.
Calcineurin is required for the transcriptional activation of cytokines and the activation of various transcription factors, including NFAT, NFκB, and AP-1, involved in T cell receptor (TCR)-mediated signaling.
The regulation of calcineurin depends on changes in intracellular calcium concentrations and the activity of protein kinase C.
TCR activation results in PKC inducing the hyperphosphorylation of Cabin-1, which facilitates the high-affinity binding of Cabin-1 to calcineurin. This complex formation inhibits calcineurin activity and attenuates TCR-mediated signaling.
Cabin-1 also associates directly with MEF-2 proteins, a family of transcription factors that regulate apoptosis signaling in T cells. This association between Cabin-1 and MEF-2 leads to the inhibition of MEF-2-mediated gene transcription and the inhibition of apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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