Thermo Fisher Scientific GPR182 Polyclonal Antibody
인간 GPR182 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 면역조직화학(IHC)용으로 적합하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태, 1.0 mg/mL 농도, 4°C 또는 -20°C 저장 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from C-terminus of human GPR182 / ADMR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550273 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human: 100%
- Gorilla, Gibbon: 94%
Target Information
Adrenomedullin (ADM) is a hypotensive peptide belonging to the peptide superfamily that includes calcitonin gene-related peptide (CGRP) and amylin. ADM was first identified in the adrenal medulla, where it is highly expressed, and is also produced by most contractile cells. It is upregulated during sepsis and ischemia.
Three distinct receptors bind ADM:
- ADM receptor (L1)
- RDC-1
- Calcitonin Receptor-Like Receptor (CRLR)
CRLR associates with receptor activity-modifying proteins (RAMPs), which determine ligand specificity:
- CRLR + RAMP1 → binds CGRP
- CRLR + RAMP2 or RAMP3 → binds ADM
The ADM receptor is a seven-transmembrane G protein-coupled receptor, highly expressed in heart, brain, skeletal muscle, immune system, adrenal gland, and liver. It mediates ADM signaling via G proteins that activate adenylate cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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