Thermo Fisher Scientific GPR18 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human GPR18, validated for IHC(P) and ELISA. High specificity and purity via antigen affinity chromatography. Suitable for detection of GPR18 in immune and reproductive tissues. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | - |
| ELISA | Assay-dependent | - |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human GPR18 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550271 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gorilla, Gibbon, Monkey: 100%
- Marmoset, Bat, Elephant, Horse: 94%
- Bovine, Rabbit, Pig: 89%
- Mouse, Rat, Pufferfish: 83%
For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
The G-protein-coupled receptor (GPCR) superfamily comprises an estimated 600–1,000 members and represents the largest known class of molecular targets with therapeutic potential.
GPR18 is an orphan G protein-coupled receptor expressed at high levels in the testis, small intestine, and immune-related cells such as lymphocytes, thymus, and spleen.
It acts as a receptor for endogenous lipid neurotransmitters, some of which also interact with cannabinoid receptors.
Known GPR18 agonists or partial agonists include:
N-Arachidonoylglycine, Abnormal cannabidiol, O-1602, AM-251, Cannabidiol, delta 9-Tetrahydrocannabinol, N-arachidonoyl ethanolamine, and Arachidonylcyclopropylamide.
Antagonists include synthetic cannabidiol-related compounds CID-85469571 and O-1918.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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