Thermo Fisher Scientific RPL7A Monoclonal Antibody (OTI3C5), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

• 재구성 시, 증류수 100 µL를 첨가하여 최종 농도 약 1 mg/mL로 조제 권장
• Conjugation 실험용으로 사용할 경우, 추가 desalting 과정 권장
  (예: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882)

Target Information

Cytoplasmic ribosomes are organelles that catalyze protein synthesis and consist of a small 40S subunit and a large 60S subunit. These subunits contain four RNA species and about 80 distinct proteins. The RPL7A gene encodes a component of the 60S subunit and belongs to the L7AE family of ribosomal proteins.
RPL7A can interact with nuclear hormone receptors such as the thyroid hormone receptor, inhibiting their DNA binding and transcriptional activation. The gene is part of the surfeit gene cluster and co-transcribed with several small nucleolar RNA genes (U24, U36a, U36b, U36c).
Additionally, it can form a chimeric oncogene (trk-2h) through rearrangement with the trk proto-oncogene, producing an oncoprotein containing the N-terminus of RPL7A fused to the receptor tyrosine kinase domain of trk. Multiple processed pseudogenes of RPL7A are dispersed throughout the genome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.