Thermo Fisher Scientific RMP Recombinant Rabbit Monoclonal Antibody (PD00-48)

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:1,000

Product Specifications

Product Specific Information

• Positive control: Human colon carcinoma tissue, human ovary carcinoma tissue
• Predicted band size: 60 kDa
• Subcellular Location: Nucleus, Cytoplasm, Mitochondrion, Cell projection

Target Information

This protein is involved in gene transcription regulation and acts as a transcriptional repressor with the corepressor UXT to regulate androgen receptor (AR) transcription. It may function as a tumor suppressor by repressing AR-mediated gene transcription and inhibiting anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, it associates with chromatin at the NKX3-1 promoter region. It antagonizes transcriptional modulation via hepatitis B virus X protein and plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions, protecting cells from deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a negative feedback mechanism counteracting excessive S6K1 survival signaling to BAD in response to growth factors. It mediates inhibition of PPP1CC phosphatase activity in mitochondria and coordinates nutrient-sensitive gene expression regulation in an mTOR-dependent manner. It appears to be a scaffolding protein able to assemble a prefoldin-like complex containing PFDs and proteins involved in transcription and ubiquitination. [Uniprot]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.