Thermo Fisher Scientific TSLP Receptor Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 23-231 of human CRLF2 (NP_0714312) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TSLP Receptor,uniProtId:Q9HC73-1,ncbiNodeId:9606,antigenRange:23-231,antigenLength:371,antigenImageFileName:PA5-87680_TSLP_Receptor_Q9HC73-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87680_TSLP_Receptor_Q9HC73-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.58 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804341

Product Specific Information

Immunogen sequence: QGGAAEGVQI QIIYFNLETV QVTWNASKYS RTNLTFHYRF NGDEAYDQCT NYLLQEGHTS GCLLDAEQRD DILYFSIRNG THPVFTASRW MVYYLKPSSP KHVRFSWHQD AVTVTCSDLS YGDLLYEVQY RSPFDTEWQS KQENTCNVTI EGLDAEKCYS FWVRVKAMED VYGPDTYPSD WSEVTCWQRG EIRDACAETP TPPKPKLSK; Positive Samples: 293T, Jurkat, Mouse liver, Rat brain; Cellular Location: Cell membrane, Single-pass type I membrane protein

Target Information

Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.