Thermo Fisher Scientific DUSP16 Polyclonal Antibody
인간, 마우스, 랫트에서 반응하는 DUSP16 폴리클로날 항체로 Western blot 및 ELISA에 적합합니다. 정제된 Rabbit IgG 형태이며 PBS/glycerol buffer에 보관됩니다. MAPK 경로 연구에 유용한 연구용 시약입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:6,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 416–665 of human DUSP16 (NP_085143.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.33 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804344 |
Product Specific Information
Immunogen sequence:
SLHGFSSSED ALEYYKPSTT LDGTNKLCQF SPVQELSEQT PETSPDKEEA SIPKKLQTAR PSDSQSKRLH SVRTSSSGTA QRSLLSPLHR SGSVEDNYHT SFLFGLSTSQ QHLTKSAGLG LKGWHSDILA PQTSTPSLTS SWYFATESSH FYSASAIYGG SASYSAYSCS QLPTCGDQVY SVRRRQKPSD RADSRRSWHE ESPFEKQFKR RSCQMEFGES IMSENRSREE LGKVGSQSSF SGSMEIIEVS
Positive Samples: HeLa, A-549, K-562, HepG2, Mouse liver
Cellular Location: Cytoplasm, Cytoplasmic vesicle, Nucleus
Target Information
Dual-specificity phosphatases (DUSPs) are a heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. They can dephosphorylate both tyrosine and serine/threonine residues.
DUSP16, also known as MKP-7, dephosphorylates MAPK proteins ERK, JNK, and p38 with distinct specificity. MKPs contain a conserved C-terminal catalytic domain and an N-terminal Cdc25-like domain. MAPK activation cascades regulate processes such as cellular proliferation, apoptosis, differentiation, and stress responses.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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