Thermo Fisher Scientific Human DMPK, GST Tag Recombinant Protein

Applications

• Kinase Assay (KA): Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
• For larger sizes, prepare aliquots to reduce freeze/thaw cycles (do not prepare aliquots below 20 µL).
• Never store kinase diluted.
• Properly stored at -80°C, guaranteed for 6 months from date of purchase.
• Protein Form: Full Length

Target Information

DMPK is a serine/threonine kinase expressed in muscle and nerve tissues. Mutations in the untranslated region of the DMPK gene are characteristic of myotonic dystrophy. The encoded protein interacts with Rho family GTPases and phosphorylates substrates such as myogenin, the β-subunit of L-type calcium channels, and phospholemman. The 3′ untranslated region contains CTG trinucleotide repeats (5–37 copies), and expansion to 50–5,000 copies causes myotonic dystrophy type I, with severity increasing with repeat number. Repeat expansion leads to chromatin condensation and disruption of gene expression in the region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.