Thermo Fisher Scientific PUM1 Polyclonal Antibody
Rabbit polyclonal antibody against human PUM1 protein for WB, ICC/IF, and ELISA applications. High specificity and affinity purified. Suitable for research use in RNA-binding protein studies. Supplied in liquid form with glycerol for stability.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–130 of human Pumilio 1 (NP_055491.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.88 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805419 |
Product Specific Information
- Immunogen sequence:
MSVACVLKRK AVLWQDSFSP HLKHHPQEPA NPNMPVVLTS GTGSQAQPQP AANQALAAGT HSSPVPGSIG VAGRSQDDAM VDYFFQRQHG EQLGGGGSGG GGYNNSKHRW PTGDNIHAEH QVRSMDELNH - Positive Samples: HepG2, SH-SY5Y, Mouse liver
- Cellular Location: Cytoplasm, Cytoplasmic granule, P-body
Target Information
PUM1 (pumilio homolog 1) is a sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3′-UTR of mRNA targets. It belongs to the PUF family of evolutionarily conserved RNA-binding proteins. PUM1 recognizes the consensus sequence 5′-UGUANAUA-3′, known as the Pumilio Response Element (PRE), related to the Nanos Response Element (NRE). It mediates repression through recruitment of the CCR4-POP2-NOT deadenylase complex, leading to translational inhibition and mRNA degradation. Mutations in PUM1 can cause spinocerebellar ataxia 47.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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