Thermo Fisher Scientific POLR3H Polyclonal Antibody
POLR3H 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 Immunocytochemistry에 사용 가능하며, 인간, 마우스, 랫트 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Thermo Fisher Scientific POLR3H Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human POLR3H (Accession Q9Y535), corresponding to amino acid residues V153–S203 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850995 |
Product Specific Information
Antibody detects endogenous levels of total RPC8.
Target Information
RPC8 is a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using ribonucleoside triphosphates as substrates. It is a peripheral component of RNA polymerase III, responsible for synthesizing small RNAs such as 5S rRNA and tRNAs.
RPC8 plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. It acts as a nuclear and cytosolic DNA sensor involved in innate immune response, recognizing non-self dsDNA that serves as a template for transcription into dsRNA.
Non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-κB activation through the RIG-I pathway.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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