Thermo Fisher Scientific Phospho-ABL1/ABL2 (Tyr393) Polyclonal Antibody
ABL1/ABL2 단백질의 Tyr393 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합하며, 인간, 마우스, 영장류 시료에 반응. 1 mg/mL 농도의 액상 형태로, PBS 및 50% glycerol 버퍼에 저장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ABL1 (Accession P00519), corresponding to amino acid residues around phosphorylated Tyr393 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2818277 |
Product Specific Information
This antibody detects endogenous levels of ABL1/2 only when phosphorylated at Tyr393, which has been historically referenced as Tyr412.
Target Information
The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including:
- 90–95% of chronic myelocytic leukemia (CML)
- 20–25% of adult acute lymphoblastic leukemia (ALL)
- 2–5% of pediatric ALL
In these leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding an activated Abl protein-tyrosine kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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