Thermo Fisher Scientific Mesothelin Chimeric Recombinant Rabbit Monoclonal Antibody (11-25)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Specificity:
This antibody binds the human mesothelin protein, which is highly expressed in many human cancers, including the majority of pancreatic adenocarcinomas, ovarian cancers, and mesotheliomas.

Target Information

Mesothelin was originally identified as a differentiation antigen of mesotheliomas, ovarian cystadenocarcinomas, and pancreatic adenocarcinomas. It is a glycosylphosphatidylinositol (GPI)-anchored, cell-surface glycoprotein predominantly secreted by mesothelial cells.
Although expressed at restricted levels in normal pleural, pericardial, and peritoneal membranes, aberrant expression is observed in various cancers such as endometrioid uterine adenocarcinomas and squamous cell carcinomas of the esophagus, stomach, lung, and cervix.

Proteolytic cleavage of Mesothelin yields a soluble fragment known as megakaryocyte potentiating factor (MPF), which stimulates megakaryocyte colony formation in murine bone marrow. MPF is suggested to be involved in megakaryocyte proliferation and platelet production.

High expression levels of Mesothelin and MPF in cancerous tissues, compared to limited expression in normal tissues, suggest their involvement in tumorigenesis. Both have been shown to promote tumor cell proliferation, migration, anchorage-independent growth, and tumor progression, implicating them in heterotypic cell adhesion and metastasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.