Thermo Fisher Scientific HLA-DMB Polyclonal Antibody
Thermo Fisher Scientific의 HLA-DMB Polyclonal Antibody는 인간 HLA-DMB 단백질을 인식하는 토끼 유래 IgG 항체로, WB 및 ELISA에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태, -20°C 보관 조건. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 19–218 of human HLA-DMB (NP_002109.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.97 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855230 |
Product Specific Information
Immunogen sequence:
GGFVAHVEST CLLDDAGTPK DFTYCISFNK DLLTCWDPEE NKMAPCEFGV LNSLANVLSQ HLNQKDTLMQ RLRNGLQNCA THTQPFWGSL TNRTRPPSVQ VAKTTPFNTR EPVMLACYVW GFYPAEVTIT WRKNGKLVMP HSSAHKTAQP NGDWTYQTLS HLALTPSYGD TYTCVVEHTG APEPILRDWT PGLSPMQTLK
Target Information
HLA-DMB (major histocompatibility complex, class II, DM beta), also known as D6S221E, RING7, HLA-DM histocompatibility type, beta chain, HLADMB or RING7, is a protein encoded by the HLA-DMB gene, mapped on 6p21.32.
HLA-DMB belongs to the HLA class II beta chain paralogues and forms a heterodimer with the alpha (DMA) chain, both anchored in the membrane and located in intracellular vesicles.
DM facilitates peptide loading of MHC class II molecules by releasing CLIP (class II-associated invariant chain peptide) from the binding site.
Class II molecules are expressed in antigen-presenting cells. The beta chain is approximately 26–28 kDa and its gene contains 6 exons.
HLA-DMA and -DMB encode subunits of a functional heterodimer critical for class II antigen presentation.
HLA and MHC antibodies are essential tools in Immunopeptidomics, enabling identification and characterization of neoantigens via high-performance liquid chromatography coupled with tandem mass spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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