Thermo Fisher Scientific HLA-DMB Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
GGFVAHVEST CLLDDAGTPK DFTYCISFNK DLLTCWDPEE NKMAPCEFGV LNSLANVLSQ HLNQKDTLMQ RLRNGLQNCA THTQPFWGSL TNRTRPPSVQ VAKTTPFNTR EPVMLACYVW GFYPAEVTIT WRKNGKLVMP HSSAHKTAQP NGDWTYQTLS HLALTPSYGD TYTCVVEHTG APEPILRDWT PGLSPMQTLK

Target Information

HLA-DMB (major histocompatibility complex, class II, DM beta), also known as D6S221E, RING7, HLA-DM histocompatibility type, beta chain, HLADMB or RING7, is a protein encoded by the HLA-DMB gene, mapped on 6p21.32.
HLA-DMB belongs to the HLA class II beta chain paralogues and forms a heterodimer with the alpha (DMA) chain, both anchored in the membrane and located in intracellular vesicles.
DM facilitates peptide loading of MHC class II molecules by releasing CLIP (class II-associated invariant chain peptide) from the binding site.
Class II molecules are expressed in antigen-presenting cells. The beta chain is approximately 26–28 kDa and its gene contains 6 exons.
HLA-DMA and -DMB encode subunits of a functional heterodimer critical for class II antigen presentation.

HLA and MHC antibodies are essential tools in Immunopeptidomics, enabling identification and characterization of neoantigens via high-performance liquid chromatography coupled with tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.