Thermo Fisher Scientific TFAM Polyclonal Antibody
TFAM 단백질을 인식하는 Thermo Fisher의 rabbit polyclonal 항체로, WB 및 ICC/IF에 적합합니다. 인간 TFAM 합성 펩타이드로 면역화되었으며, 미토콘드리아 DNA 복제 및 전사 연구에 활용됩니다. 1 mg/mL 농도의 액상 형태로 제공되며, 다양한 종에 예측 반응성을 보입니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.2–2.5 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide region of human TFAM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2255882 |
Product Specific Information
- Recommended positive controls: bEND.3, Hep3B, HepG2, Jurkat, K562
- Predicted reactivity: Cow (92%), Dog (83%), Guinea Pig (75%), Horse (92%), Mouse (75%), Pig (92%), Rabbit (83%)
- By Western blot, PA1-24435 detects the ~29 kDa TFAM protein
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Mitochondrial transcription factor A (TFAM) is a crucial protein encoded by nuclear genes and transported from the cytoplasm to mitochondria, where it plays a key role in maintaining and expressing mitochondrial DNA (mtDNA). It regulates mtDNA replication and transcription, ensuring proper mitochondrial function.
Structurally, TFAM contains an LC3 interacting region (LIR) motif that binds to autophagy proteins such as LC3. This interaction supports the autolysosomal pathway, eliminating leaked mtDNA and limiting inflammation. TFAM levels vary across tissues, influencing mitochondrial function: high TFAM can repress mtDNA expression in skeletal muscle, while in cardiac tissue, balanced TFAM-to-mtDNA ratios preserve oxidative phosphorylation (OXPHOS) capacity.
Disruptions in TFAM can lead to mitochondrial dysfunction and are implicated in neurodegeneration and diseases related to mtDNA stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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