Thermo Fisher Scientific CD42b Monoclonal Antibody (AK2), FITC
인간 CD42b 항원을 인식하는 마우스 단클론 항체로, FITC 형광 표지되어 유세포분석(FACS)에 적합합니다. 혈소판 활성화 및 응집 관련 연구에 활용되며, 고순도 Protein A 정제 및 안정적 저장 조건을 제공합니다.
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Thermo Fisher Scientific CD42b Monoclonal Antibody (AK2), FITC
Applications
- Flow Cytometry (Flow)
Tested Dilution: Neat-1:10
Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AK2 |
| Immunogen | Proprietary Immunogen |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. Store in the dark. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_928314 |
Additional Formats
- Unconjugated (MA5-16564)
- Biotin (MA5-16563)
- PE (MA5-16566)
- Custom conjugation available upon request
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
Mouse anti-Human CD42b antibody, clone AK2 recognizes the human CD42b cell surface antigen, also known as platelet glycoprotein GP1B.
Target Information
CD42b is a platelet activation marker involved in coagulation and aggregation. It interacts with extracellular matrix and adhesion molecules and is regulated by VEGF and PDGF. CD42b forms part of the GPIb-IX-V receptor complex, critical for platelet-rich thrombus formation by tethering platelets to thrombogenic surfaces.
CD42b binds to von Willebrand factor (VWF), thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1, and P-selectin. Its extracellular domain contributes to metastasis. CD42b is expressed on platelets and megakaryocytes in bone marrow. Mutations in CD42b are associated with Bernard-Soulier syndrome and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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