Thermo Fisher Scientific ZFHX1B Monoclonal Antibody (2H5)
인간 ZFHX1B(ZEB2) 단백질을 인식하는 Mouse IgG2b 단일클론 항체. Western blot 및 ELISA에 적합하며, 비결합형 액상 형태로 제공. PBS(pH 7.4) buffer에 보존제 없이 저장하며, -20°C에서 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2H5 |
| Immunogen | ZFHX1B (NP_055610.1, 1115–1214 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SITPQGYSDS EERESMPRDG ESEKEHEKEG EDGYGKLGRQ DGDEEFEEEE EESENKSMDT DPETIRDEEE TGDHSMDDSS EDGKMETKSD HEEDNMEDGM
Target Information
ZEB2, also known as Smad interacting-protein 1, is a nuclear DNA-binding transcriptional repressor that interacts with activated SMADs. Like ZEB1, it inhibits transcription of the E-cadherin gene and induces epithelial-mesenchymal transition (EMT), a process controlling cell migration during embryonic development and wound healing. ZEB2 also protects cells from DNA damage-induced apoptosis, suggesting a role in tumor progression. It is frequently observed in the cytoplasm of various cancer tissues, indicating regulated localization. Mutations in ZEB2 are associated with Hirschsprung disease and Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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