Thermo Fisher Scientific MTSS1 Monoclonal Antibody (2G9)
Human MTSS1 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot과 ELISA에 적합. 세포 성장 및 이동 관련 연구에 활용. 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific MTSS1 Monoclonal Antibody (2G9)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G9 |
| Immunogen | MTSS1 (AAH23998, 346–445 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GVLPAPPDGP EERGEHSPES PSVGEGPQGV TSMPSSMWSG QASVNPPLPG PKPSIPEEHR QAIPESEAED QEREPPSATV SPGQIPESDP ADLSPRDTPQ
Target Information
Metastasis suppressor protein 1 (MTSS1) [MIM, “missing in metastasis”] was first identified as missing transcripts from metastatic bladder and prostate cancer cells.
MTSS1 is a 755 amino acid protein with multidomain scaffolding function. It includes a proline-rich/SH3 binding region, a serine-rich region with EGF or PDGF/Src consensus sites, and an actin-binding WH2 motif at the C-terminus. The N-terminal IMD domain interacts with membranes and bundles actin filaments.
MTSS1 binds actin monomers and regulates cytoskeletal reorganization, interacting with cortactin via SH3 domains and enhancing Arp2/3-dependent actin polymerization.
It plays a key role in cell motility, morphogenesis, and sonic hedgehog/Gli signaling. MTSS1 is expressed in spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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