Thermo Fisher Scientific CD2 Monoclonal Antibody (RM2-5), PE, eBioscience

Applications and Tested Dilution

• Application: Flow Cytometry (Flow)
• Tested Dilution: 0.25 µg/test
• Publications: View 5 publications

Product Specifications

Available Formats

• Unconjugated
• Biotin
• FITC
• Functional Grade
• NovaFluor Blue 510
• NovaFluor Blue 610-70S
• NovaFluor Blue 660-120S
• NovaFluor Blue 690
• NovaFluor Red 685
• NovaFluor Red 700
• NovaFluor Red 755
• NovaFluor Yellow 610
• NovaFluor Yellow 660
• NovaFluor Yellow 700
• NovaFluor Yellow 755
• Request custom conjugation

Product Specific Information

The RM2-5 monoclonal antibody reacts with the mouse CD2 molecule, an approximately 50–55 kDa cell surface receptor expressed by all mouse lymphocytes. In mice, CD2 is expressed from the pre-B cell stage to mature B cells, differing from human expression. CD2 serves as a ligand for CD48 and participates in T-cell adhesion and activation.

• Applications Reported: Flow cytometric analysis
• Applications Tested: Tested on mouse splenocytes and bone marrow cells
• Recommended Usage: ≤0.25 µg per test (100 µL final volume, 10⁵–10⁸ cells/test)
• Excitation: 488–561 nm
• Emission: 578 nm
• Laser Compatibility: Blue, Green, Yellow-Green Laser
• Filtration: 0.2 µm post-manufacturing filtered

Target Information

CD2 (LFA-2) is a monomeric surface antigen (45–58 kDa) found on human T-lymphocytes and some NK cells, but not on B cells. It mediates adhesion between T cells and antigen-presenting cells via interaction with CD58. CD2 expression increases upon T-cell activation, enhancing cell-cell adhesion. CD2 deficiency can affect immune responses and inflammation regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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