Thermo Fisher Scientific MLLT11 Polyclonal Antibody
MLLT11 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체로, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. 인간, 생쥐, 랫트 반응성이 있으며, Protein A로 정제된 액상 포맷으로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human MLLT11 (amino acids 41–90) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The gene variously symbolized ALL1, HRX, or MLL, located on 11q23, has been shown to fuse with multiple translocation partners in leukemia cases. Translocations such as t(1;11)(q21;q23) that fuse the MLL gene to a gene on chromosomal band 1q21 have been identified in infants with acute myelomonocytic leukemia.
The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes a 90-amino-acid protein, highly expressed in the thymus but not in peripheral lymphoid tissues. Unlike its restricted expression in normal hematopoietic tissue, it is expressed in all leukemic cell lines tested.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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