Thermo Fisher Scientific CCR9 Recombinant Rat Monoclonal Antibody (9B1)

Applications

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Neutralization (Neu)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

Specificity: 9B1 antibody recognizes CCR9 at the N-terminus.
CCR9 is a member of the G protein coupled receptor family and is involved in T cell development in the thymus and in gut-associated immune response.
Mouse CCR9 is highly expressed on different stages of thymocytes and upregulated on CD4+CD8+ cells.

Target Information

The protein encoded by this gene is a member of the beta chemokine receptor family.
It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors.
Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammatory conditions.
The specific ligand of this receptor is CCL25.
This gene is differentially expressed by T lymphocytes of the small intestine and colon, suggesting a role in thymocyte recruitment and development that may permit functional specialization of immune responses in different segments of the gastrointestinal tract.
This gene is mapped to the chemokine receptor gene cluster region.
Two alternatively spliced transcript variants have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.