Thermo Fisher Scientific TIMD2 Polyclonal Antibody
Mouse TIMD2 단백질을 인식하는 Goat Polyclonal Antibody로, Western blot 및 IHC(Frozen)에서 검증됨. 낮은 교차 반응성과 높은 특이성을 가지며, 항원 친화 크로마토그래피로 정제. 연구용으로만 사용 가능.
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- PA547995
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.1 µg/mL
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: 1–15 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host/Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse TIM-2 (Met1–Asn229) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606503 |
Product Specific Information
In direct ELISAs and Western blots, less than 2% cross-reactivity with recombinant human TIM-1 and recombinant mouse TIM-3 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
TIM-2 recognizes T-cell immunoglobulin mucin 2, a transmembrane glycoprotein and member of the immunoglobulin superfamily. It is expressed by activated lymphocytes, developmentally in the 8-cell embryo and blastocyst, and preferentially up-regulated in Th2 cells while down-regulated in Th1 cells.
Tim-2 acts as a negative regulator of Th2 cells and plays a critical role in the development of atopic disease and other Th2-biased immune responses. It also serves as a receptor for Semaphorin 4A, expressed on dendritic cells and B cells, contributing to axonal migration guidance and enhancing T cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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