Thermo Fisher Scientific KREMEN2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.1 µg/mL

-

Flow Cytometry (Flow)

0.25 µg per million cells

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Kremen-2 Gln19-Ala364 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:KREMEN2,uniProtId:Q8NCW0-1,ncbiNodeId:9606,antigenRange:19-364,antigenLength:462,antigenImageFileName:PA5-47997_KREMEN2_Q8NCW0-1_Goat.svg,antigenImageFileNamePDP:PA5-47997_KREMEN2_Q8NCW0-1_Goat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2606572

Product Specific Information

In direct ELISAs and Western blots, approximately 35% cross-reactivity with recombinant mouse Kremen-2 is observed and 25% cross-reactivity with recombinant human Kremen-1 is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.