Thermo Fisher Scientific KREMEN2 Polyclonal Antibody
Thermo Fisher Scientific의 KREMEN2 Polyclonal Antibody는 인간 KREMEN2 단백질을 인식하는 염소 유래 IgG 항체입니다. Western blot 및 유세포 분석에 적합하며, 높은 특이성과 재현성을 제공합니다. 동결건조 형태로 제공되며, 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 0.25 µg per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human Kremen-2 (Gln19–Ala364) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606572 |
Product Specific Information
- In direct ELISAs and Western blots, approximately 35% cross-reactivity with recombinant mouse Kremen-2 and 25% cross-reactivity with recombinant human Kremen-1.
- Reconstitute at 0.2 mg/mL in sterile PBS before use.
Target Information
Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins containing extracellular kringle, WSC, and CUB domains with an intracellular region lacking conserved motifs.
Kremens bind a subset of secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity, modulating the canonical Wnt signaling pathway via the Wnt–Frizzled–LRP5/6 receptor complex.
Recent studies indicate that KREMEN2 regulates bone remodeling, suggesting potential therapeutic relevance in bone loss disorders.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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