Thermo Fisher Scientific NMDAR2B Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitute in 500 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide is homologous in mouse and rat.
• Specificity: NMDAR2B.

Target Information

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) are involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency, underlying memory and learning.
They play a role in neuronal development and are implicated in neurological disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death.
Overexpression of the NR2B subunit is associated with enhanced learning and memory, while aged, memory-impaired animals show reduced NR2B expression.
Phosphorylation at Tyr1472 on NR2B may increase synaptic NMDAR expression, contributing to synaptic plasticity.
NMDAR2B forms part of a heterotrimeric receptor complex with NR1, NR2, and NR3 subunits.
Dysfunction of NMDAR2B is linked to epileptic encephalopathy and autosomal dominant 6-related intellectual disability.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.