Thermo Fisher Scientific NMDAR2B Polyclonal Antibody
Rabbit polyclonal antibody targeting NMDAR2B for WB and IHC applications. Recognizes human, mouse, and rat species. Lyophilized form with PBS buffer, no preservative. Useful for neuroscience research on NMDA receptor function and synaptic plasticity.
- 카탈로그번호
- OSN00029G-500UG
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous (PubMed) | - | View 2 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of human NMDAR2B (GRIN2B) conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in mouse and rat.
- Specificity: NMDAR2B.
Target Information
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) are involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency, underlying memory and learning.
They play a role in neuronal development and are implicated in neurological disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death.
Overexpression of the NR2B subunit is associated with enhanced learning and memory, while aged, memory-impaired animals show reduced NR2B expression.
Phosphorylation at Tyr1472 on NR2B may increase synaptic NMDAR expression, contributing to synaptic plasticity.
NMDAR2B forms part of a heterotrimeric receptor complex with NR1, NR2, and NR3 subunits.
Dysfunction of NMDAR2B is linked to epileptic encephalopathy and autosomal dominant 6-related intellectual disability.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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