Thermo Fisher Scientific Neuroligin 1, 2 Polyclonal Antibody
Neuroligin 1 및 2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC에 사용 가능. 사람, 마우스, 랫트에 반응. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 권장. 신경 시냅스 형성과 관련된 연구용에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide to human Neuroligin 1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous with Neuroligin 2.
- Specificity: Neuroligin 1 and Neuroligin 2.
Target Information
Neuroligins are a family of plasma membrane proteins with an N-terminal hydrophobic domain, a large esterase homology domain, a single transmembrane region, a short cytoplasmic domain, and an EF-hand binding domain.
Members include Neuroligin 1, Neuroligin 2, and Neuroligin 3, which are expressed in excitatory neuronal synaptic clefts.
Neuroligins play a key role in the formation and remodeling of CNS synapses by binding to β-neurexins, a family of neuronal cell surface proteins. Neuroexin 1β binds to the EF-hand domain of Neuroligin 1 and requires calcium ions. Neuroligins also interact with PSD-95, which may recruit ion channels and neurotransmitter receptors to synapses.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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