Thermo Fisher Scientific Estrogen Receptor alpha Recombinant Rabbit Monoclonal Antibody (107)
Recombinant rabbit monoclonal antibody targeting human Estrogen Receptor alpha (ERα). Suitable for Western blot applications. High specificity and purity (Protein A purified, 1 mg/mL). Storage at 4°C short term, -20°C long term. For research use only.
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Applications
- Western Blot (WB): Tested dilution 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 107 |
| Immunogen | Synthetic peptide corresponding to the center region of Human ER alpha/ESR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866582 |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, upon binding to estrogen, undergoes a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. This binding allows ER to regulate gene transcription positively or negatively through coactivator or corepressor recruitment.
Two forms of estrogen receptors exist: alpha (ESR1) and beta (ESR2). Alternative RNA splicing produces at least four known ER-alpha isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa). Estrogen receptors are widely expressed in various tissues, essential for sexual development and reproductive function, and also play roles in bone and other tissues. They are implicated in pathological processes such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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